Dear Pharmacist, I take Lisinopril for high blood pressure. I read that when taking this medication I should try to avoid using ibuprofen over the counter. Take Hydrochlorothiazide with a full glass of water and drink plenty of water during the day while taking this medication. If you don't, you can become dehydrated. If you don't, you can become dehydrated. Can I take Hydrochlorothiazide with Tylenol? There is no known interaction between Hydrochlorothiazide and Tylenol in our records. However, an interaction may still exist. There is no known interaction between Hydrochlorothiazide and Tylenol in our records. ibuprofen oral and valsartan-hydrochlorothiazide oral ibuprofen oral decreases effects of valsartan-hydrochlorothiazide oral by pharmacodynamic antagonism. NSAIDs decrease synthesis of vasodilating renal prostaglandins, and thus affect fluid homeostasis and may diminish antihypertensive effect. It is recommended that if you are taking lisinopril you should be advised to avoid moderately high or high potassium dietary intake. This can cause high levels of potassium in your blood. Do not use salt substitutes or potassium supplements while taking lisinopril, unless your doctor has told you to. Doctors give trusted answers on uses, effects, side-effects, and cautions: Dr. Tripp on can i take xanax and hydrochlorothiazide: Yes you can take them together. Search Sign up free For pain relief,you can take tab.Acetaminophen.It is safe to take with lisinopril & is also available as OTC(over the counter) without prescription. Please feel free to ask if you have any other question. Summary. Drug interactions are reported among people who take Hydrochlorothiazide and Ibuprofen together. This study is created by eHealthMe based on reports of 3,920 people who take Hydrochlorothiazide and Ibuprofen from FDA, and is updated regularly. Ibuprofen is an anti-inflammatory and fever-reducing medication. It can be used to treat pain and inflammation associated with many conditions such as menstrual cramps, headaches, arthritis, muscle pain,and toothaches. 1. J Gerontol A Biol Sci Med Sci. 1996 Mar;51(2):M74-9. The impact of ibuprofen on the efficacy of antihypertensive treatment with hydrochlorothiazide in elderly persons.